منابع مشابه
E-cadherin regulates Eph family members
Cadherins comprise a family of calcium-dependent cell adhesion molecules that regulate many basic developmental processes and are fundamental for the maintenance of both embryonic and adult tissue structure (reviewed in Yap et al., 1997; Stappert and Kemler, 1999). The most studied member of the cadherin protein family is E-cadherin, a transmembrane adhesion protein localized in the adherens ju...
متن کاملExpression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells.
Cadherins, a multigene family of transmembrane glycoproteins, mediate Ca(2+)-dependent intercellular adhesion. They are thought to be essential for the control of morphogenetic processes, including myogenesis. Here we report the identification and characterization of the cDNA of another member of the cadherin family, M-cadherin (M for muscle), from differentiating muscle cells. The longest open...
متن کاملAutoregulation of E-cadherin expression by cadherin–cadherin interactions
Transcriptional repression of E-cadherin, characteristic of epithelial to mesenchymal transition, is often found also during tumor cell invasion. At metastases, migratory fibroblasts sometimes revert to an epithelial phenotype, by a process involving regulation of the E-cadherin-beta-catenin complex. We investigated the molecular basis of this regulation, using human colon cancer cells with abe...
متن کاملA Role for the Cadherin Family of Cell Adhesion Molecules in Hippocampal Long-Term Potentiation
The cadherins are a family of cell-cell adhesion molecules that mediate Ca2+-dependent homophilic interactions between cells and transduce signals by interacting with cytoplasmic proteins. In the hippocampus, immunostaining combined with confocal microscopy revealed that both neural- (N-) and epithelial- (E-) cadherin are present at synaptic sites, implying a role in synaptic function. Pretreat...
متن کاملA Striking Organization of a Large Family of Human Neural Cadherin-like Cell Adhesion Genes
We have identified 52 novel human cadherin-like genes organized into three closely linked clusters. Comparison of the genomic DNA sequences with those of representative cDNAs reveals a striking genomic organization similar to that of immunoglobulin and T cell receptor gene clusters. The N-terminal extracellular and transmembrane domains of each cadherin protein are encoded by a distinct and unu...
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ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 1997
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.25.1-2_39